Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2.
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Kim SF, Huri DA, Snyder SH
Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2.
Science. 2005 Dec 23;310(5756):1966-70.
- PubMed ID
- 16373578 [ View in PubMed]
- Abstract
Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-nitrosylates it, enhancing COX-2 catalytic activity. Selectively disrupting iNOS-COX-2 binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction between two inflammatory systems may inform the development of anti-inflammatory drugs.