Antithrombin III: structural and functional aspects.
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Mourey L, Samama JP, Delarue M, Choay J, Lormeau JC, Petitou M, Moras D
Antithrombin III: structural and functional aspects.
Biochimie. 1990 Aug;72(8):599-608.
- PubMed ID
- 2126464 [ View in PubMed]
- Abstract
Antithrombin III is a plasma glycoprotein responsible for thrombin inhibition in the blood coagulation cascade. The X-ray structure of its cleaved form has been determined and refined to 3.2 A resolution. The overall topology is similar to that of alpha 1-antitrypsin, another member of the serpin (serine protease inhibitor) superfamily. The biological activity of antithrombin III is mediated by a polysaccharide, heparin. The binding site of this effector is described. A possible structural transition from the native to the cleaved structure is discussed.