Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.
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Yoo H, Jeon B, Jeon MS, Lee H, Kim TY
Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.
FEBS Lett. 2008 Sep 22;582(21-22):3249-53. doi: 10.1016/j.febslet.2008.08.017. Epub 2008 Aug 26.
- PubMed ID
- 18755188 [ View in PubMed]
- Abstract
The 12/15-lipoxygenase (12/15-LOX) pathways of arachidonate metabolism have been implicated in the pathogenesis of psoriasis. Since UV photo-therapy is a commonly used technique for inhibiting cell proliferation and inflammation in skin diseases, we hypothesized that UV-irradiation may affect 12/15-LOX expression which might regulate cell proliferation. In this study, we showed that UV-irradiation suppressed 12-LOX expression, whereas up-regulated 15-LOX expression. Treatment with the 15-LOX metabolites sufficiently suppressed insulin-like growth factor II-induced 12-LOX expression and blocked cell cycle progression. On the basis of our findings, we think that the 15-LOX metabolites may inhibit epidermal hyperplasia in psoriasis by regulating 12-LOX expression.