Gemcitabine and Pemetrexed disodium in treating breast cancer.

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Adjei AA

Gemcitabine and Pemetrexed disodium in treating breast cancer.

Oncology (Williston Park). 2001 Feb;15(2 Suppl 3):34-7.

PubMed ID

11252887 [ View in PubMed

]

Abstract

Pemetrexed disodium (Alimta, LY231514) is a novel, multitargeted antifolate that inhibits thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyl transferase. This agent is broadly active in a wide variety of solid tumors, including breast cancer. Pemetrexed disodium has also shown clinically relevant activity in combination with gemcitabine (Gemzar). This combination is being evaluated for the treatment of metastatic breast cancer.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Pemetrexed	Dihydrofolate reductase	Protein	Humans	Yes	Inhibitor	Details
Pemetrexed	Thymidylate synthase	Protein	Humans	Yes	Inhibitor	Details
Pemetrexed	Trifunctional purine biosynthetic protein adenosine-3	Protein	Humans	Yes	Inhibitor	Details