Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.
Article Details
- CitationCopy to clipboard
Holmes K, Roberts OL, Thomas AM, Cross MJ
Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.
Cell Signal. 2007 Oct;19(10):2003-12. Epub 2007 Jun 12.
- PubMed ID
- 17658244 [ View in PubMed]
- Abstract
Vascular endothelial growth factors (VEGFs) regulate vascular development, angiogenesis and lymphangiogenesis by binding to a number of receptors. VEGFR-1 is required for the recruitment of haematopoietic stem cells and the migration of monocytes and macrophages, VEGFR-2 regulates vascular endothelial function and VEGFR-3 regulates lymphatic endothelial cell function. Over the last decade, considerable progress has been made in delineating the VEGFR-2 specific intracellular signalling cascades leading to proliferation, migration, survival and increased permeability, each of which contributes to the angiogenic response. Furthermore, therapeutic inhibition of VEGFR-2 action is now having an impact in the clinic for the treatment of a number of diseases.