Pks, a raf-related sequence in humans.

Article Details


Mark GE, Seeley TW, Shows TB, Mountz JD

Pks, a raf-related sequence in humans.

Proc Natl Acad Sci U S A. 1986 Sep;83(17):6312-6.

PubMed ID
3529082 [ View in PubMed

A human fetal liver cDNA library was screened at reduced hybridization stringency for v-raf-related sequences. In addition to the expected c-raf-1 cDNA, a second sequence was isolated. Comparison of the second gene (pks) to the other raf-related sequences revealed nucleotide homologies of 71%. The predicted amino acid sequence of the kinase domain is sufficiently similar to that of v-raf to suggest that pks may encode a polypeptide that exhibits serine/threonine kinase activity. The expression of pks mRNA (2.7 kilobases long) is elevated in peripheral blood mononuclear cells isolated from two patients with angioimmunoblastic lymphadenopathy with dysproteinemia, a disease in which autoantibodies are produced following the lymphoproliferative activation of B cells. Analysis of somatic cell hybrids for segregation of the pks locus revealed the presence of an additional locus closely related to the pks sequence.

DrugBank Data that Cites this Article

NameUniProt ID
Serine/threonine-protein kinase A-RafP10398Details