Investigation of striatal dopamine D2 receptor acquisition following prenatal neuroleptic exposure.

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Schmidt MH, Lee T

Investigation of striatal dopamine D2 receptor acquisition following prenatal neuroleptic exposure.

Psychiatry Res. 1991 Mar;36(3):319-28.

PubMed ID

1676523 [ View in PubMed

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Abstract

To test the hypothesis that neuroleptic blockade impairs the development of striatal dopamine D2 receptors, pregnant rats were given haloperidol, thiothixene, or trifluoperazine for gestational days 15-18 (short-term exposure) or days 5-20 (long-term exposure). All of the drugs were demonstrated to cross the placenta and enter the fetal brains equally well. Striatal dopamine D2 receptors of the pups were assayed on postnatal day 14. Neither receptor density nor receptor affinity was altered significantly by the short- or long-term prenatal neuroleptic treatment.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Trifluoperazine	Dopamine D2 receptor	Protein	Humans	Yes	Antagonist	Details