Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
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Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O
Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
DNA Res. 1998 Feb 28;5(1):31-9.
- PubMed ID
- 9628581 [ View in PubMed]
- Abstract
As an extension of a series of projects for sequencing human cDNA clones derived from relatively long transcripts, we herein report the entire sequences of 100 newly determined cDNA clones with the potential of coding for large proteins in vitro. The cDNA clones were isolated from size-fractionated human brain cDNA libraries with insert sizes between 4.5 and 8.3 kb. The sequencing of these clones revealed that the average size of the cDNA inserts and of their open reading frames was 5.3 kb and 2.8 kb (930 amino acid residues), respectively. Homology search against public databases indicated that the predicted coding sequences of 86 clones exhibited significant similarities to known genes; 51 of them (59%) were related to those for cell signaling/communication, nucleic acid management, and cell structure/motility. All the clones characterized in this study are accompanied by their expression profiles in 14 human tissues examined by reverse transcription-coupled polymerase chain reaction and the chromosomal mapping data.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID tRNA wybutosine-synthesizing protein 4 O60294 Details Serine palmitoyltransferase 2 O15270 Details Laminin subunit alpha-5 O15230 Details Voltage-dependent calcium channel subunit alpha-2/delta-2 Q9NY47 Details Histone deacetylase 5 Q9UQL6 Details Neurexin-1 Q9ULB1 Details TRAF2 and NCK-interacting protein kinase Q9UKE5 Details NUAK family SNF1-like kinase 1 O60285 Details Serine/threonine-protein kinase PRP4 homolog Q13523 Details Lysine-specific histone demethylase 1A O60341 Details Adenylate cyclase type 3 O60266 Details Adenylate cyclase type 9 O60503 Details