Gene structure of human indoleamine 2,3-dioxygenase.
Article Details
- CitationCopy to clipboard
Kadoya A, Tone S, Maeda H, Minatogawa Y, Kido R
Gene structure of human indoleamine 2,3-dioxygenase.
Biochem Biophys Res Commun. 1992 Nov 30;189(1):530-6.
- PubMed ID
- 1449503 [ View in PubMed]
- Abstract
Two genomic DNA clones that encode human indoleamine 2,3-dioxygenase (IDO) were isolated from the human genomic DNA library using the IDO cDNA as a probe, and their restriction maps and partial nucleotide sequences were determined. The human IDO gene spanned 15 kilobase pairs with ten exons. The 5' terminus of the IDO mRNA was 33 nucleotides upstream of the translation initiation codon ATG. The 5' flanking region contained ISRE, X-box, and Y-box like sequences. Southern blot analysis of the human genomic DNA indicated that the human IDO gene was present in a single copy in the genome.