Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization.
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Nedwin GE, Naylor SL, Sakaguchi AY, Smith D, Jarrett-Nedwin J, Pennica D, Goeddel DV, Gray PW
Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization.
Nucleic Acids Res. 1985 Sep 11;13(17):6361-73.
- PubMed ID
- 2995927 [ View in PubMed]
- Abstract
Human Tumor Necrosis Factor and Lymphotoxin are cytotoxic proteins which have similar biological activities and share 30 percent amino acid homology. The single copy genes which encode these proteins share several structural features: each gene is approximately three kilobase pairs in length and is interrupted by three introns. In addition, these genes are closely linked and have been mapped to human chromosome 6. However, only the last exons of both genes, which code for more than 80 percent of each secreted protein, are significantly homologous (56 percent).