Structure of human urokinase plasminogen activator in complex with its receptor.

Article Details

Citation

Huai Q, Mazar AP, Kuo A, Parry GC, Shaw DE, Callahan J, Li Y, Yuan C, Bian C, Chen L, Furie B, Furie BC, Cines DB, Huang M

Structure of human urokinase plasminogen activator in complex with its receptor.

Science. 2006 Feb 3;311(5761):656-9.

PubMed ID
16456079 [ View in PubMed
]
Abstract

The urokinase plasminogen activator binds to its cellular receptor with high affinity and initiates signaling cascades that are implicated in pathological processes including tumor growth, metastasis, and inflammation. We report the crystal structure at 1.9 angstroms of the urokinase receptor complexed with the urokinase amino-terminal fragment and an antibody against the receptor. The three domains of urokinase receptor form a concave shape with a central cone-shaped cavity where the urokinase fragment inserts. The structure provides insight into the flexibility of the urokinase receptor that enables its interaction with a wide variety of ligands and a basis for the design of urokinase-urokinase receptor antagonists.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Urokinase plasminogen activator surface receptorQ03405Details
Urokinase-type plasminogen activatorP00749Details