Molecular mechanisms and regulation of opioid receptor signaling.
Article Details
- CitationCopy to clipboard
Law PY, Wong YH, Loh HH
Molecular mechanisms and regulation of opioid receptor signaling.
Annu Rev Pharmacol Toxicol. 2000;40:389-430.
- PubMed ID
- 10836142 [ View in PubMed]
- Abstract
Cloning of multiple opioid receptors has presented opportunities to investigate the mechanisms of multiple opioid receptor signaling and the regulation of these signals. The subsequent identification of receptor gene structures has also provided opportunities to study the regulation of receptor gene expression and to manipulate the concentration of the gene products in vivo. Thus, in the current review, we examine recent advances in the delineation basis for the multiple opioid receptor signaling, and their regulation at multiple levels. We discuss the use of receptor knockout animals to investigate the function and the pharmacology of these multiple opioid receptors. The reasons and basis for the multiple opioid receptor are addressed.