Opioid receptor affinity for agonist-antagonist analgesics.

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Jacobs AM, Youngblood F

Opioid receptor affinity for agonist-antagonist analgesics.

J Am Podiatr Med Assoc. 1992 Oct;82(10):520-4.

PubMed ID

1361946 [ View in PubMed

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Abstract

Analgesic medications are distributed to a variety of receptors within the central nervous system. Activity at these receptors (mu 1, mu, sigma, delta, kappa) results in both the beneficial pain-relieving effects of analgesics as well as undesirable side effects. The mixed agonist-antagonist class of analgesics offers the potential benefit of greater receptor site selectivity while diminishing the incidence of adverse sequelae, such as respiratory depression. Traditionally, it has been suggested that mixed agonist-antagonist medications may be associated with decreased analgesic effectiveness. However, newer agents of this mixed class may result in effective analgesia while diminishing the incidence of side effects.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Dezocine	Mu-type opioid receptor	Protein	Humans	Yes	Agonist	Details