Estrogen receptor-beta mRNA variants in human and murine tissues.
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Lu B, Leygue E, Dotzlaw H, Murphy LJ, Murphy LC, Watson PH
Estrogen receptor-beta mRNA variants in human and murine tissues.
Mol Cell Endocrinol. 1998 Mar 16;138(1-2):199-203.
- PubMed ID
- 9685228 [ View in PubMed]
- Abstract
Estrogen receptor (ER)-beta mRNA splice variants have been identified in human breast tumors as well as normal human and mouse ovarian, uterine and mammary tissues. In both species transcripts deleted in exons 5 or 6, or 5 + 6 have been characterized by RT-PCR followed by cloning and sequencing. In mouse tissues an ER-beta transcript containing 54 nucleotides inserted in frame between exons 5 and 6 was identified. Interestingly, no equivalent of the mouse inserted transcript was detected in any of the four human tissues analyzed.