Primary structure and expression of a functional human glucocorticoid receptor cDNA.
Article Details
- CitationCopy to clipboard
Hollenberg SM, Weinberger C, Ong ES, Cerelli G, Oro A, Lebo R, Thompson EB, Rosenfeld MG, Evans RM
Primary structure and expression of a functional human glucocorticoid receptor cDNA.
Nature. 1985 Dec 19-1986 Jan 1;318(6047):635-41.
- PubMed ID
- 2867473 [ View in PubMed]
- Abstract
Identification of complementary DNAs encoding the human glucocorticoid receptor predicts two protein forms, of 777 (alpha) and 742 (beta) amino acids, which differ at their carboxy termini. The proteins contain a cysteine/lysine/arginine-rich region which may define the DNA-binding domain. Pure radiolabelled glucocorticoid receptor, synthesized in vitro, is immunoreactive and possesses intrinsic steroid-binding activity characteristic of the native glucocorticoid receptor.