Rational design of an organometallic glutathione transferase inhibitor.
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Ang WH, Parker LJ, De Luca A, Juillerat-Jeanneret L, Morton CJ, Lo Bello M, Parker MW, Dyson PJ
Rational design of an organometallic glutathione transferase inhibitor.
Angew Chem Int Ed Engl. 2009;48(21):3854-7. doi: 10.1002/anie.200900185.
- PubMed ID
- 19396894 [ View in PubMed]
- Abstract
Double trouble: A hybrid organic-inorganic (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the organic moiety acts as the active-site inhibitor (see picture). The mechanism of inhibition was studied using a range of biophysical and biochemical methods.