The IGF-I receptor in cancer research.
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Baserga R
The IGF-I receptor in cancer research.
Exp Cell Res. 1999 Nov 25;253(1):1-6.
- PubMed ID
- 10579905 [ View in PubMed]
- Abstract
The type 1 insulin-like growth factor receptor (IGF-IR) plays an important role in both normal and abnormal growth. It is particularly important in anchorage-independent growth. Impairment of its function causes apoptosis of tumor cells and inhibition of tumor growth in experimental animals. However, the IGF-IR can also induce differentiation, and eventually cell death, of certain types of cells. Its major substrates, IRS-1 and Shc, determine whether the IGF-IR will transform cells or will cause their differentiation.