Drotrecogin alfa (activated) approved for treatment of severe sepsis.

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Poe K

Drotrecogin alfa (activated) approved for treatment of severe sepsis.

J Am Pharm Assoc (Wash). 2002 May-Jun;42(3):520-2.

PubMed ID

12030642 [ View in PubMed

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Abstract

Drotrecogin alfa (activated) is a recombinant form of human activated protein C that has been shown to reduce mortality in severely septic patients with a high risk of death. Given the complexity of the inclusion and exclusion criteria, the stability and unique duration of infusion, and the cost of treatment, therapy with this agent should be carefully considered to ensure its appropriate use.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Drotrecogin alfa	Coagulation factor V	Protein	Humans	Yes	Inhibitor	Details