KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.
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Wang HS, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, McKinnon D
KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.
Science. 1998 Dec 4;282(5395):1890-3.
- PubMed ID
- 9836639 [ View in PubMed]
- Abstract
The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.