Heterogeneous expression of four MAP kinase isoforms in human tissues.

Article Details

Citation

Gonzalez FA, Raden DL, Rigby MR, Davis RJ

Heterogeneous expression of four MAP kinase isoforms in human tissues.

FEBS Lett. 1992 Jun 15;304(2-3):170-8.

PubMed ID
1319925 [ View in PubMed
]
Abstract

Mitogen-activated protein kinases (MAP kinases) are a group of closely related enzymes implicated in signal transduction pathways. We report the molecular cloning of four human proteins (p40mapk, p41mapk, p44mapk and p63mapk) with high homology to members of the MAP kinase family. Sequence analysis demonstrated that p44mapk and p63mapk were the products of distinct genes. However, the p40mapk and p41mapk were found to be related, and are likely to result from alternative processing of transcripts from a single gene. The heterogeneous expression of these human MAP kinase isoforms in different tissues may reflect the diversity of signal transduction pathways in differentiated cells.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Mitogen-activated protein kinase 1P28482Details
Mitogen-activated protein kinase 3P27361Details
Mitogen-activated protein kinase 4P31152Details