Receptor specificity defines algogenic properties of propofol and fospropofol.
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Patwardhan A, Edelmayer R, Annabi E, Price T, Malan P, Dussor G
Receptor specificity defines algogenic properties of propofol and fospropofol.
Anesth Analg. 2012 Oct;115(4):837-40. Epub 2012 May 14.
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- 22584560 [ View in PubMed]
- Abstract
BACKGROUND: Propofol-evoked injection site pain is not observed with fospropofol. We hypothesized that unlike propofol, fospropofol does not activate the irritant receptor, transient receptor potential 1 (TRPA1). METHODS: We tested the hypothesis using electrophysiology and behavioral studies. RESULTS: Our data demonstrate that propofol (100 muM) evokes an inward current only in TRPA1-expressing neurons. However, fospropofol (100 muM and 1 mM) is unable to evoke depolarizing currents in either TRPA1-positive or TRPA1-negative neurons. Both propofol and fospropofol produced general anesthesia. CONCLUSIONS: The lack of algogenic activity in fospropofol is most likely the result of its inability to activate TRPA1 on nociceptors.
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