A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins.
Article Details
- CitationCopy to clipboard
Smith CA, Davis T, Anderson D, Solam L, Beckmann MP, Jerzy R, Dower SK, Cosman D, Goodwin RG
A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins.
Science. 1990 May 25;248(4958):1019-23.
- PubMed ID
- 2160731 [ View in PubMed]
- Abstract
Tumor necrosis factor alpha and beta (TNF-alpha and TNF-beta) bind surface receptors on a variety of cell types to mediate a wide range of immunological responses, inflammatory reactions, and anti-tumor effects. A cDNA clone encoding an integral membrane protein of 461 amino acids was isolated from a human lung fibroblast library by direct expression screening with radiolabeled TNF-alpha. The encoded receptor was also able to bind TNF-beta. The predicted cysteine-rich extracellular domain has extensive sequence similarity with five proteins, including nerve growth factor receptor and a transcriptionally active open reading frame from Shope fibroma virus, and thus defines a family of receptors.