Kindlin 2 forms a transcriptional complex with beta-catenin and TCF4 to enhance Wnt signalling.
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Yu Y, Wu J, Wang Y, Zhao T, Ma B, Liu Y, Fang W, Zhu WG, Zhang H
Kindlin 2 forms a transcriptional complex with beta-catenin and TCF4 to enhance Wnt signalling.
EMBO Rep. 2012 Aug;13(8):750-8. doi: 10.1038/embor.2012.88. Epub 2012 Jun 15.
- PubMed ID
- 22699938 [ View in PubMed]
- Abstract
Kindlin 2, as a focal adhesion protein, controls integrin activation. However, the association of Kindlin 2 with cancer-related signalling pathways is unknown. Here we identified a new direct interaction between Kindlin 2 and the active beta-catenin. Importantly, Kindlin 2 forms a tripartite complex with beta-catenin and TCF4. Mechanistically, Kindlin 2 selectively strengthens the occupancy of beta-catenin on the Wnt target gene Axin2 and enhances Axin2 gene expression. Functionally, the beta-catenin-Axin2-Snail cascade is required for Kindlin 2-induced tumour cell invasion. Our data indicate that Kindlin 2 is a new regulator of Wnt signalling, providing a mechanistic insight into the role of Kindlin 2 in cancer progression.