A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.
Article Details
- CitationCopy to clipboard
Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, McNulty D, Blumenthal MJ, Heys JR, Landvatter SW, et al.
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.
Nature. 1994 Dec 22-29;372(6508):739-46.
- PubMed ID
- 7997261 [ View in PubMed]
- Abstract
Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-photoaffinity-labelled chemical probes, the target of these compounds was identified as a pair of closely related mitogen-activated protein kinase homologues, termed CSBPs. Binding of the pyridinyl-imidazole compounds inhibited CSBP kinase activity and could be directly correlated with their ability to inhibit cytokine production, suggesting that the CSBPs are critical for cytokine production.