The gene organisation of the human beta 2 integrin subunit (CD18).
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Weitzman JB, Wells CE, Wright AH, Clark PA, Law SK
The gene organisation of the human beta 2 integrin subunit (CD18).
FEBS Lett. 1991 Dec 2;294(1-2):97-103.
- PubMed ID
- 1683838 [ View in PubMed]
- Abstract
We have studied the gene of the human beta 2 integrin subunit (CD18) and found it to be organised into 16 exons spanning a region of about 40 kb. All exon/intron boundaries conform to the GT/AG splicing consensus. The exons coding for the cysteine-rich region, which has been postulated to consist of 3 or 4 repeating elements, are not organised correspondingly. Transcription of the gene initiates from multiple sites which may be due to the absence of an upstream TATA box. The polyadenylation site is also heterogeneous. Five different sites were identified over a stretch of 10 bases.