Tipping the balance: Cdk2 enables Myc to suppress senescence.

Article Details

Citation

Hydbring P, Larsson LG

Tipping the balance: Cdk2 enables Myc to suppress senescence.

Cancer Res. 2010 Sep 1;70(17):6687-91. doi: 10.1158/0008-5472.CAN-10-1383. Epub 2010 Aug 16.

PubMed ID
20713526 [ View in PubMed
]
Abstract

Intrinsic tumor-suppressor pathways protect healthy cells from transformation by activated oncogenes like MYC or RAS through induction of apoptosis or cellular senescence, respectively. However, when expressed together, MYC and RAS evade these barriers and initiate tumorigenesis. Although Ras suppresses Myc-induced apoptosis, the role of Myc in this cooperation has remained undefined. In a recent report, we showed that Myc represses Ras-induced senescence, thereby overcoming the second major barrier of tumorigenesis. Inhibition of Ras-induced senescence required specific phosphorylation of Myc by cyclin-dependent kinase 2 (Cdk2) and was abrogated by pharmacologic Cdk2 inhibitors, urging a reevaluation of this kinase as a therapeutic target in Myc- or Ras-driven tumors.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Cyclin-dependent kinase 2P24941Details
Myc proto-oncogene proteinP01106Details