Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide.
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Nelkin BD, Rosenfeld KI, de Bustros A, Leong SS, Roos BA, Baylin SB
Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide.
Biochem Biophys Res Commun. 1984 Sep 17;123(2):648-55.
- PubMed ID
- 6148938 [ View in PubMed]
- Abstract
Messenger RNAs for calcitonin (CT) and calcitonin gene related peptide (CGRP) have been detected in a human medullary thyroid carcinoma cell line. DNA sequences of their cloned cDNAs, and genomic restriction mapping, indicate that both mRNAs probably originate from a single gene; the separate mRNAs are derived by alternative processing. The calcitonin gene is expressed in 10 of 10 examined culture lines of human lung cancer; most of these lines express a higher ratio of CGRP to CT specific mRNA than does the medullary thyroid carcinoma cell line.