The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue.
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Hirshberg M, Stockley RW, Dodson G, Webb MR
The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue.
Nat Struct Biol. 1997 Feb;4(2):147-52.
- PubMed ID
- 9033596 [ View in PubMed]
- Abstract
The crystal structure of human rac1, a member of the rho family of small G-proteins, complexed with the non-hydrolysable GTP analogue, guanosine-5'-(beta gamma-imino)triphosphate (GMPPNP), has been determined by X-ray analysis at a resolution of 1.38 A. Comparison with the structure of H-ras indicates that rac1 has an extra alpha-helical domain that is characteristic of the rho G proteins, and may be involved in the signalling pathway of this family.