Inhibitory effect of dichlorvos on arterial smooth muscle contraction.

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Ebeigbe AB, Campbell PI

Inhibitory effect of dichlorvos on arterial smooth muscle contraction.

Pharmacol Res Commun. 1986 Mar;18(3):283-91.

PubMed ID
3725847 [ View in PubMed
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Abstract

The effect of the organophosphate pesticide, dichlorvos, on the contractile responses of isolated rat tail arteries has been studied. Dichlorvos (10(-8)-10(-4) M) had no effect on baseline tension, but relaxed 10(-7) M norepinephrine (NE), 10(-7) M 5-HT or 100 mM KCl contractions dose-dependently. Dichlorvos also inhibited CaCl2 dose-response curves in K+-depolarized strips, as well as depressing both phasic and tonic components of NE-induced contractions. The results suggest a direct relaxant effect of dichlorvos on arterial smooth muscle by a mechanism probably related to interference with Ca2+ supply.

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