Tec homology (TH) adjacent to the PH domain.
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Vihinen M, Nilsson L, Smith CI
Tec homology (TH) adjacent to the PH domain.
FEBS Lett. 1994 Aug 22;350(2-3):263-5.
- PubMed ID
- 8070576 [ View in PubMed]
- Abstract
The pleckstrin homology (PH) domain is extended in the Btk kinase family by a region designated the TH (Tec homology) domain, which consists of about 80 residues preceding the SH3 domain. The TH domain contains a conserved 27 amino acid stretch designated the Btk motif and a proline-rich region. Sequence similarity was found to a putative Ras GTPase activating protein and a human interferon-gamma binding protein both in the PH domain and the Btk motif region. SLK1/SSP31 protein kinase and a non-catalytic p85 subunit of PI-3 kinase had similarity only with the proline rich region. The identification of a PH domain extension in some signal transduction proteins in different species suggests that this region is involved in protein-protein interactions.