The plasmid-encoded arsenical resistance pump: an anion-translocating ATPase.
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Rosen BP
The plasmid-encoded arsenical resistance pump: an anion-translocating ATPase.
Res Microbiol. 1990 Mar-Apr;141(3):336-41.
- PubMed ID
- 1704144 [ View in PubMed]
- Abstract
An anion-translocating ATPase has been identified as the product of the arsenical resistance operon of resistance plasmid R773. When expressed in Escherichia coli this ATP-driven oxyanion pump catalyses extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit enzyme produces resistance to arsenite and antimonite. A third gene, arsC, expands the substrate specificity to allow for arsenate pumping and resistance.