Lasalocid toxicosis is inadequately quantified for horses.

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Kronfeld DS

Lasalocid toxicosis is inadequately quantified for horses.

Vet Hum Toxicol. 2002 Aug;44(4):245-7.

PubMed ID
12136977 [ View in PubMed
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Abstract

The current estimate of LD50, 21.5 mg/kg BW, for lasalocid in horses is based on an analysis of 8 data from 4 horses that died at dose levels of 15, 21, 22 and 26 mg/kg. This analysis neglected 14 data from another 6 horses that survived at dose levels of 5, 10,14, 18, 19, 25, 29 and 50 mg/kg, and so was biased by selection of data. An examination of all the data indicates they are insufficient to determine the LD50. In contrast, the whole data set suggests a lowest toxic dose of 15 mg/kg, although this estimate was based on only 1 affected animal in 8 tests from 5 to 15 mg/kg in an unbalanced experiment and thus needs confirmation.

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