Biosynthesis of monensin.

Article Details

Citation
Copy to clipboard

Day LE, Chamberlin JW, Gordee EZ, Chen S, Gorman M, Hamill RL, Ness T, Weeks RE, Stroshane R

Biosynthesis of monensin.

Antimicrob Agents Chemother. 1973 Oct;4(4):410-4.

PubMed ID
4791301 [ View in PubMed
]
Abstract

The biosynthesis of monensin by Streptomyces cinnamonensis was studied by using (14)C-labeled glucose, acetate, propionate, butyrate, and methionine. The results indicated that the antibiotic is synthesized from five acetate, seven propionate, and one butyrate molecules. The o-methyl group of monensin is derived from methionine, whereas the terminal hydroxymethyl group is incorporated from acetate.

DrugBank Data that Cites this Article

Drugs