Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development.
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Mekalanos JJ, Swartz DJ, Pearson GD, Harford N, Groyne F, de Wilde M
Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development.
Nature. 1983 Dec 8-14;306(5943):551-7.
- PubMed ID
- 6646234 [ View in PubMed]
- Abstract
Nucleotide sequence and deletion analysis have been used to identify the regulatory and coding sequences comprising the cholera toxin operon (ctx). Incorporation of defined in vitro-generated ctx deletion mutations into Vibrio cholerae by in vivo genetic recombination produced strains which have practical value in cholera vaccine development.