Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.

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Perna NT, Plunkett G 3rd, Burland V, Mau B, Glasner JD, Rose DJ, Mayhew GF, Evans PS, Gregor J, Kirkpatrick HA, Posfai G, Hackett J, Klink S, Boutin A, Shao Y, Miller L, Grotbeck EJ, Davis NW, Lim A, Dimalanta ET, Potamousis KD, Apodaca J, Anantharaman TS, Lin J, Yen G, Schwartz DC, Welch RA, Blattner FR

Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.

Nature. 2001 Jan 25;409(6819):529-33.

PubMed ID
11206551 [ View in PubMed
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Abstract

The bacterium Escherichia coli O157:H7 is a worldwide threat to public health and has been implicated in many outbreaks of haemorrhagic colitis, some of which included fatalities caused by haemolytic uraemic syndrome. Close to 75,000 cases of O157:H7 infection are now estimated to occur annually in the United States. The severity of disease, the lack of effective treatment and the potential for large-scale outbreaks from contaminated food supplies have propelled intensive research on the pathogenesis and detection of E. coli O157:H7 (ref. 4). Here we have sequenced the genome of E. coli O157:H7 to identify candidate genes responsible for pathogenesis, to develop better methods of strain detection and to advance our understanding of the evolution of E. coli, through comparison with the genome of the non-pathogenic laboratory strain E. coli K-12 (ref. 5). We find that lateral gene transfer is far more extensive than previously anticipated. In fact, 1,387 new genes encoded in strain-specific clusters of diverse sizes were found in O157:H7. These include candidate virulence factors, alternative metabolic capacities, several prophages and other new functions--all of which could be targets for surveillance.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
2-deoxyglucose-6-phosphate phosphataseQ7ADF8Details
Uracil-DNA glycosylaseQ8X444Details
Sulfoxide reductase catalytic subunit YedYQ8XB74Details
50S ribosomal protein L22P61177Details
50S ribosomal protein L4P60725Details
Probable UbiX-like flavin prenyltransferaseP69772Details
Peptidoglycan D,D-transpeptidase FtsIP0AD69Details
Arginine/agmatine antiporterP60063Details
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidaseP0AF14Details
GrlRQ7DB61Details