Cloning and characterization of human histone deacetylase 8.

Article Details


Van den Wyngaert I, de Vries W, Kremer A, Neefs J, Verhasselt P, Luyten WH, Kass SU

Cloning and characterization of human histone deacetylase 8.

FEBS Lett. 2000 Jul 28;478(1-2):77-83.

PubMed ID
10922473 [ View in PubMed

To date, seven different human histone deacetylases (HDACs) have been identified, which fall into two distinct classes. We have isolated and characterized a cDNA encoding a novel human HDAC, which we name HDAC8. HDAC8 shows a high degree of sequence similarity to HDAC1 and HDAC2 and thus belongs to the class I of HDACs. HDAC8 is expressed in a variety of tissues. Human cells overexpressing HDAC8 localize the protein in sub-nuclear compartments whereas HDAC1 shows an even nuclear distribution. In addition, the HDAC8 gene is localized on the X chromosome at position q13, which is close to the XIST gene and chromosomal breakpoints associated with preleukemia.

DrugBank Data that Cites this Article

NameUniProt ID
Histone deacetylase 8Q9BY41Details