Experimental and theoretical studies of albendazole, oxibendazole, and tioxidazole.
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McCracken RO, Lipkowitz KB
Experimental and theoretical studies of albendazole, oxibendazole, and tioxidazole.
J Parasitol. 1990 Apr;76(2):180-5.
- PubMed ID
- 2319417 [ View in PubMed]
- Abstract
An investigation of the therapeutic effectiveness of albendazole (ABZ, methyl 5-[propylthio]benzimidazole-2-carbamate), oxibendazole (OBZ, methyl 5-[n-propoxy]benzimidazole-2-carbamate), and tioxidazole (TIOX, methyl 6-[n-propoxy]benzothiazole-2-carbamate) against Hymenolepis diminuta in experimentally infected rats is reported. All of the anthelmintics tested were effective therapeutically as a single oral dose against adult tapeworms, however, at different dose levels. The rank order of in vivo anthelmintic potency was ABZ greater than OBZ greater than TIOX. Molecular modeling revealed that drug efficacy depends on the orientation of the propyl group at position 5 on the heterocyclic ring system and on the magnitude of the molecular dipole moment.
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