Molecular evolution and zinc ion binding motif of leukotriene A4 hydrolase.
Article Details
- CitationCopy to clipboard
Toh H, Minami M, Shimizu T
Molecular evolution and zinc ion binding motif of leukotriene A4 hydrolase.
Biochem Biophys Res Commun. 1990 Aug 31;171(1):216-21.
- PubMed ID
- 1975494 [ View in PubMed]
- Abstract
Leukotriene A4 (LTA4) hydrolase belongs to the aminopeptidase N family. In order to investigate the molecular evolution and physiological significance of LTA4 hydrolase, the enzymes belonging to the family were aligned and a phylogenetic tree was constructed. From the alignment, it was found that three residues involved in zinc binding and one residue of the active sites of aminopeptidases N were conserved in LTA4 hydrolase. In agreement with the observation, LTA4 hydrolase is a zinc protein as determined by atomic absorption spectroscopy.