Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase.
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Uchida K, Morita T, Sato T, Ogura T, Yamashita R, Noguchi S, Suzuki H, Nyunoya H, Miwa M, Sugimura T
Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase.
Biochem Biophys Res Commun. 1987 Oct 29;148(2):617-22.
- PubMed ID
- 3120710 [ View in PubMed]
- Abstract
The complete nucleotide sequence of human fibroblast poly(ADP-ribose) polymerase cDNA was determined. The cDNA contains an open reading frame for a 1014 amino acid polypeptide. In the DNA binding domain of poly(ADP-ribose) polymerase, there are predicted alpha-helix-turn-alpha-helix structures and two sequences each of about 100 amino acids that are similar to each other containing potential cysteine-zinc DNA binding structures. Within the 3' untranslated region, there is an AT-rich sequence containing ATTTA, a possible mRNA destabilizer.