Effect of cefovecin on the fecal flora of healthy dogs.

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Citation

Lawrence M, Kukanich K, Kukanich B, Heinrich E, Coetzee JF, Grauer G, Narayanan S

Effect of cefovecin on the fecal flora of healthy dogs.

Vet J. 2013 Oct;198(1):259-66. doi: 10.1016/j.tvjl.2013.04.010. Epub 2013 May 20.

PubMed ID
23702279 [ View in PubMed
]
Abstract

Cefovecin is an extended-spectrum long-acting third generation cephalosporin used to treat canine infections. The study objective was to determine the effect of cefovecin on the absolute number and antimicrobial susceptibility of fecal enteric bacteria in healthy dogs. Fourteen Beagles were randomly assigned to a treated (n=7, 8 mg/kg cefovecin subcutaneously on day 1) or untreated (n=7) group. LC/MS was used to determine plasma cefovecin concentration on day 14. E. coli, enterococci, and Salmonella were isolated and enumerated from fecal samples collected on days 0, 3, 7, 14, and 28. Antimicrobial resistance was determined using disc diffusion, MIC, and detected using PCR for the blaCMY-2 gene on select isolates. Mean plasma concentration of cefovecin on day 14 was 9.59 mug/mL in treated dogs; untreated dogs had no measurable plasma cefovecin. The absolute number of E. coli was lower in treated dogs on day 3 (P

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