The death-associated protein kinases: structure, function, and beyond.

Article Details


Bialik S, Kimchi A

The death-associated protein kinases: structure, function, and beyond.

Annu Rev Biochem. 2006;75:189-210.

PubMed ID
16756490 [ View in PubMed

Death-associated protein kinase (DAPk) is the founding member of a newly classified family of Ser/Thr kinases, whose members not only possess significant homology in their catalytic domains, but also share cell death-associated functions. The realization that DAPk is a tumor suppressor gene, whose expression is lost in multiple tumor types, has spurred a flurry of interest in the kinase family and produced an impressive body of literature concerning its function, regulation, and connection to disease. The DAPk family has been linked to several cell death-related signaling pathways, and functions other than cell death have also been proposed. This review presents a thorough structural analysis of the kinases, discusses methods of regulation, clarifies their cellular targets and functions, and shows how these functions are integrated. Although many gaps in our knowledge still remain, the data generated to date can be combined to delineate a place for the DAPk family within the general cell death-signaling network.

DrugBank Data that Cites this Article

NameUniProt ID
Death-associated protein kinase 1P53355Details
Death-associated protein kinase 3O43293Details
Death-associated protein kinase 2Q9UIK4Details