Characteristics of equilibrium reaction of zolazepam.

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Hong WH, Szulczewski DH

Characteristics of equilibrium reaction of zolazepam.

J Pharm Sci. 1981 Jun;70(6):691-3.

PubMed ID
7252822 [ View in PubMed
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Abstract

The equilibrium reaction of zolazepam, a pyrazolodiazepinone, was studied and analyzed using the approach used previously for other pyrazolodiazepinone derivatives. The intrinsic ring closure equilibrium constant for this reaction was approximately 100 times larger than that observed for pyrazolodiazepinones studied previously. This study illustrates that the diazepinone ring can dominate in equilibrium mixtures formed at pH values far below the pKa of the corresponding form.

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