Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus.
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Muesing MA, Smith DH, Cabradilla CD, Benton CV, Lasky LA, Capon DJ
Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus.
Nature. 1985 Feb 7-13;313(6002):450-8.
- PubMed ID
- 2982104 [ View in PubMed]
- Abstract
The 9,213-nucleotide structure of the AIDS/lymphadenopathy virus has been determined from molecular clones representing the integrated provirus and viral RNA. The sequence reveals that the virus is highly polymorphic and lacks significant nucleotide homology with type C retroviruses characterized previously. Together with an analysis of the two major viral subgenomic RNAs, these studies establish the coding frames for the gag, pol and env genes and predict the expression of a novel gene at the 3' end of the genome unrelated to the X genes of HTLV-1 and -II.