Organization of the human pro-alpha 2(I) collagen gene.
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de Wet W, Bernard M, Benson-Chanda V, Chu ML, Dickson L, Weil D, Ramirez F
Organization of the human pro-alpha 2(I) collagen gene.
J Biol Chem. 1987 Nov 25;262(33):16032-6.
- PubMed ID
- 2824475 [ View in PubMed]
- Abstract
Sixty kilobases of cloned DNA containing the entire human pro-alpha 2(I) collagen gene and 22 kilobases of flanking sequences have been isolated. Like the homologous avian gene, the 1366 amino acid residues of the human pre-pro-alpha 2(I) chain are encoded by 52 exons, whose relative locations and sizes have been determined. Analysis of the 5'- and 3'-untranslated regions have confirmed their exact lengths, as well as conclusively established the nature of five polymorphic mRNA transcripts.