17-beta-hydroxysteroid dehydrogenase type 2
Details
- Name
- 17-beta-hydroxysteroid dehydrogenase type 2
- Kind
- protein
- Synonyms
- 17-beta-HSD 2
- 20 alpha-hydroxysteroid dehydrogenase
- 20-alpha-HSD
- E2DH
- EDH17B2
- Estradiol 17-beta-dehydrogenase 2
- Microsomal 17-beta-hydroxysteroid dehydrogenase
- SDR9C2
- Short chain dehydrogenase/reductase family 9C member 2
- Testosterone 17-beta-dehydrogenase
- Gene Name
- HSD17B2
- UniProtKB Entry
- P37059Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0009867|17-beta-hydroxysteroid dehydrogenase type 2 MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL FSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG AEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELL LMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVT MFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD YFAKRHFGQDKPMPRALRMPNYKKKAT
- Number of residues
- 387
- Molecular Weight
- 42784.75
- Theoretical pI
- 8.62
- GO Classification
- Functionsestradiol 17-beta-dehydrogenase [NAD(P)+] activityProcessesandrogen metabolic process / estrogen biosynthetic process / steroid metabolic processComponentsintracellular membrane-bounded organelle
- General Function
- Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity
- Specific Function
- 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
- Pfam Domain Function
- adh_short (PF00106)
- Signal Regions
- Not Available
- Transmembrane Regions
- 4-24
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0009868|Estradiol 17-beta-dehydrogenase 2 (HSD17B2) ATGAGCACTTTCTTCTCGGACACAGCATGGATCTGCCTGGCTGTCCCCACAGTACTATGT GGGACAGTATTTTGCAAATACAAGAAGAGCTCAGGGCAGCTGTGGAGCTGGATGGTCTGC CTGGCAGGCCTCTGTGCAGTCTGCCTGCTCATCCTGTCCCCTTTTTGGGGCTTGATCCTC TTCTCGGTGTCATGCTTCCTCATGTATACTTACTTATCTGGCCAAGAATTGTTACCTGTG GATCAGAAGGCAGTCCTGGTGACAGGTGGTGATTGCGGGCTTGGCCATGCTTTGTGCAAG TATCTGGATGAGCTGGGCTTCACGGTATTTGCCGGAGTTTTGAATGAAAATGGCCCAGGA GCTGAGGAATTGCGAAGAACCTGCTCTCCGCGCCTCTCGGTGCTCCAAATGGACATCACG AAGCCAGTGCAGATAAAAGATGCTTACAGCAAGGTTGCAGCAATGCTGCAGGACAGAGGA CTGTGGGCTGTGATCAACAATGCTGGGGTGCTTGGCTTTCCAACTGATGGGGAGCTTCTT CTTATGACTGACTACAAACAATGCATGGCCGTGAACTTCTTTGGAACTGTGGAGGTCACA AAGACGTTTTTGCCTCTTCTTAGAAAATCCAAAGGGAGGCTGGTGAATGTCAGCAGCATG GGAGGAGGGGCCCCAATGGAAAGGCTGGCATCTTATGGCTCATCAAAGGCGGCTGTGACC ATGTTCTCATCAGTTATGAGACTGGAGCTTTCCAAGTGGGGAATTAAAGTTGCTTCCATC CAACCTGGAGGCTTCCTAACAAATATCGCAGGCACCAGTGACAAGTGGGAAAAGCTGGAG AAGGACATTCTGGACCACCTCCCCGCTGAGGTACAGGAAGACTACGGCCAGGACTACATC TTAGCACAGCGGAATTTCCTCCTATTGATCAACTCGTTAGCCAGCAAGGACTTCTCTCCG GTGCTGCGGGACATCCAGCATGCTATCTTGGCGAAGAGCCCTTTTGCCTATTACACGCCA GGGAAAGGCGCTTACTTGTGGATCTGCCTTGCTCACTATTTGCCTATTGGCATATATGAT TACTTTGCTAAAAGACATTTTGGCCAAGACAAGCCCATGCCCAGAGCTCTAAGAATGCCT AACTACAAGAAAAAGGCCACCTAG
- Chromosome Location
- 16
- Locus
- 16q23.3
- External Identifiers
Resource Link UniProtKB ID P37059 UniProtKB Entry Name DHB2_HUMAN GenBank Protein ID 306462 GenBank Gene ID L11708 GeneCard ID HSD17B2 GenAtlas ID HSD17B2 HGNC ID HGNC:5211 KEGG ID hsa:3294 IUPHAR/Guide To Pharmacology ID 3094 NCBI Gene ID 3294 - General References
- Wu L, Einstein M, Geissler WM, Chan HK, Elliston KO, Andersson S: Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity. J Biol Chem. 1993 Jun 15;268(17):12964-9. [Article]
- Labrie Y, Durocher F, Lachance Y, Turgeon C, Simard J, Labrie C, Labrie F: The human type II 17 beta-hydroxysteroid dehydrogenase gene encodes two alternatively spliced mRNA species. DNA Cell Biol. 1995 Oct;14(10):849-61. [Article]
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details NADH approved, nutraceutical unknown target Details Estradiol acetate approved, investigational, vet_approved unknown target Details Estradiol benzoate approved, investigational, vet_approved unknown target Details Estradiol cypionate approved, investigational, vet_approved unknown target Details Estradiol dienanthate approved, investigational, vet_approved unknown target Details Estradiol valerate approved, investigational, vet_approved unknown target Details