17-beta-hydroxysteroid dehydrogenase type 2

BE0000006ProteinHumansHSD17B2

Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. It is acted on by 9 drugs in DrugBank.

Gene name
HSD17B2
UniProtKB entry
P37059Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
387 residues · 42,785 Da
Also known as
17-beta-HSD 2 · 20 alpha-hydroxysteroid dehydrogenase · 20-alpha-HSD · E2DH · EDH17B2

Resolves to

Protein
UniProtP37059UniProt nameDHB2_HUMAN
Gene
HGNCHGNC:5211NCBI Gene3294GenBank306462GeneCardsHSD17B2
Pharmacology
IUPHAR/GtoPdb3094KEGGhsa:3294
Drugs

What you can answer from here — as of September 03, 2024

9DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 17-beta-hydroxysteroid dehydrogenase type 2, how selective are they, and which programs against it are still in active trials?

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