Estradiol dienanthate is an estrogen used in some combined hormonal oral contraceptives. Estradiol Dienanthate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body.
- Mechanism
- Curator reviewed
Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.
- Primary indication
- Estradiol dienanthate is not currently available in any FDA or Health Canada approved products.Curator reviewed · 1 structured indication
- Formula / weight
- C32H48O4 · 496.732 g/mol (avg)
- First approval
- Canada, 2005
- Also known as
- Estradiol dienantate
Resolves to
OVAHZPTYWMWNKO-CAHAWPIUSA-NSMILESCCCCCCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(OC(=O)CCCCCC)=CC=C4[C@H]3CC[C@]12CWhat you can answer from here — as of April 02, 2025
Which drugs share a target with Estradiol dienanthate, and which of those have an active Phase 3 trial?
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