Aminomethyltransferase, mitochondrial

BE0000010ProteinHumansAMT

The glycine cleavage system catalyzes the degradation of glycine. It is acted on by 4 drugs in DrugBank.

Gene name
AMT
UniProtKB entry
P48728Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
403 residues · 43,946 Da
Also known as
2.1.2.10 · GCST · GCVT · Glycine cleavage system T protein

Resolves to

Protein
UniProtP48728UniProt nameGCST_HUMAN
Gene
HGNCHGNC:473NCBI Gene275GenBank391721GeneCardsAMT
Pharmacology
KEGGhsa:275
Structure
PDB1WSRPDB1WSV
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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2GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aminomethyltransferase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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