5-methyltetrahydrofolic acid

DB04789InvestigationalNutraceuticalSmall molecule

5-methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. It is generated by methylenetetrahydrofolate reductase from 5,10-methylenetetrahydrofolate and used to recycle homocysteine back to methionine by 5-methyltetrahydrofolate-homocysteine methyltransferases (also called methionine...

Chemical structure of 5-methyltetrahydrofolic acid
Formula / weight
C20H25N7O6 · 459.463 g/mol (avg)
Also known as
N-Methyltetrahydrofolate · N-Methyltetrahydrofolic acid · N5-Methyltetrahydrofolate

Resolves to

Compound
UNIITYK22LML8FCAS134-35-0ChEMBLCHEMBL1221561PubChem9825434
Clinical / RWD
RxNorm1313966
Structure
InChIKeyZNOVTXRBGFNYRX-ABLWVSNPSA-NSMILESCN1C(CNC2=CC=C(C=C2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNC2=C1C(=O)N=C(N)N2
Targets
P48728AMTQ96NT5SLC46A1
Transporters
Q92887ABCC2

What you can answer from here — as of April 02, 2025

2Protein targetsEach mapped to UniProt, with action and pharmacological action
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1TransporterSubstrate / inhibitor direction, not just membership
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33Drug interactionsStructured to mechanism, not free text
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2Structured indicationsCondition, population, route and combination as fields, not prose
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22Marketed productsAcross 2 countries and 9 labellers
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2+ReferencesStructured and connected to the statements they support
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Which drugs share a target with 5-methyltetrahydrofolic acid, and which of those have an active Phase 3 trial?

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