Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

BE0000011ProteinHumansIDH3A

Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. It is acted on by 6 drugs in DrugBank.

Gene name
IDH3A
UniProtKB entry
P50213Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
366 residues · 39,591 Da
Also known as
1.1.1.41 · Isocitric dehydrogenase subunit alpha · NAD(+)-specific ICDH subunit alpha

Resolves to

Protein
UniProtP50213UniProt nameIDH3A_HUMAN
Gene
HGNCHGNC:5384NCBI Gene3419GenBank706839GeneCardsIDH3A
Pharmacology
KEGGhsa:3419
Structure
PDB5GREPDB5GRFPDB5GRH
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1GO termFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
15+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In