Acetyl-CoA acetyltransferase, mitochondrial

BE0000069ProteinHumansACAT1

This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). It is acted on by 5 drugs in DrugBank.

Gene name
ACAT1
UniProtKB entry
P24752Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
427 residues · 45,199 Da
Also known as
2.3.1.9 · ACAT · Acetoacetyl-CoA thiolase · MAT · T2

Resolves to

Protein
UniProtP24752UniProt nameTHIL_HUMAN
Gene
HGNCHGNC:93NCBI Gene38GenBank219918GeneCardsACAT1
Pharmacology
IUPHAR/GtoPdb2435KEGGhsa:38
Structure
PDB2F2SPDB2IB7PDB2IB8
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Acetyl-CoA acetyltransferase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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